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  • 399250
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399250

Sigma-Aldrich

NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem

Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.

All Photos(1)
Synonym(s):
NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem, NOHA, AcOH
Empirical Formula (Hill Notation):
C6H14N4O3 · xC2H4O2
CAS Number:
53598-01-9
Molecular Weight:
190.20 (free base basis)
MDL number:
MFCD00216150

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NG-Hydroxy-L-arginine acetate salt

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H7278

NG-Hydroxy-L-arginine acetate salt

Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem A potent, selective, competitive, and high affinity inhibitor of arginase.

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399275

Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem

A potent, selective, competitive, and high affinity inhibitor of arginase.

BEC hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1384

BEC hydrochloride

≥98% (HPLC)

ABH hydrochloride ≥98% (HPLC)

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SML1466

ABH hydrochloride

≥98% (HPLC)

N,N′-Dimethylthiourea 99%

Sigma-Aldrich

D188700

N,N′-Dimethylthiourea

99%

L-Citrulline ≥98% (TLC)

Sigma-Aldrich

C7629

L-Citrulline

≥98% (TLC)

4-(2′-Pyridylazo)-resorcinol ≥98%

Sigma-Aldrich

8.41016

4-(2′-Pyridylazo)-resorcinol

≥98%

NG-Methyl-L-arginine acetate salt ≥98% (TLC)

Sigma-Aldrich

M7033

NG-Methyl-L-arginine acetate salt

≥98% (TLC)

Ethanolamine ≥98%

Sigma-Aldrich

E9508

Ethanolamine

≥98%

4-(2-Pyridylazo)resorcinol 96%

Sigma-Aldrich

323209

4-(2-Pyridylazo)resorcinol

96%

Quality Level

100

assay

≥98% (elemental analysis)

form

solid

potency

150 μM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

Cell permeable. A key intermediate in the biosynthesis of nitric oxide by constitutive nitric oxide synthase (cNOS). NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system. A potent inhibitor of liver and macrophage arginase (Ki = 150 µM).
Cell-permeable. A key intermediate product in the biosynthesis of nitric oxide from arginine by constitutive nitric oxide synthase (cNOS). Formed by the NADPH-dependent hydroxylation of L-arginine. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450, providing an alternative biosynthetic route for the production of nitric oxide. A potent inhibitor of liver and macrophage arginase (Ki = 150 µM).

Packaging

5 mg in Plastic ampoule
Packaged under inert gas

Biochem/physiol Actions

Cell permeable: yes
Primary Target
liver and macrophage arginase

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun.193, 963.
Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun.187, 880.
Stuehr, D.J., et al. 1991. J. Biol. Chem.266, 6259.
Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun.176, 528.
Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA88, 11172.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Quality

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