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400010

Sigma-Aldrich

Caspase-1 Inhibitor I

The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

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Synonym(s):
Caspase-1 Inhibitor I, IL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
Empirical Formula (Hill Notation):
C23H32N4O8
CAS Number:
Molecular Weight:
492.52
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

assay

≥97% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 5 mg/mL
water: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C23H32N4O8/c1-12(2)20(23(35)27-21(33)13(3)24-16(11-28)10-19(31)32)26-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,24,30H,9-10H2,1-4H3,(H,25,29)(H,26,34)(H,31,32)(H,27,33,35)/t13-,16-,18-,20-/m0/s1

InChI key

KQCBPHUOVBKBPQ-SJVNDZIOSA-N

General description

A potent, specific, and reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. ICE inhibitor I is a potent, specific, and reversible inhibitor of ICE (Ki = 200 pM for human recombinant ICE). Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.

Biochem/physiol Actions

Cell permeable: no
Primary Target
caspase-1, human recombinant
Product does not compete with ATP.
Reversible: yes
Target Ki: 200 pM for human recombinant caspase-1

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Tyr-Val-Ala-Asp-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Los, M., et al. 1995. Nature375, 81.
Walker, N.P.C., et al. 1994. Cell78, 343.
Wilson, K.P., et al. 1994. Nature370, 270.
Thornberry, N.A., et al. 1992. Nature356, 768.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Caspase Inhibitor I Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor.

Sigma-Aldrich

627610

Caspase Inhibitor I

Sigma-Aldrich

Sigma-Aldrich

V116

Z-VAD-FMK

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