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  • 400010
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400010

Sigma-Aldrich

Caspase-1 Inhibitor I

The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

All Photos(1)
Synonym(s):
Caspase-1 Inhibitor I, IL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
Empirical Formula (Hill Notation):
C23H32N4O8
CAS Number:
143313-51-3
Molecular Weight:
492.52

Quality Level

100

Assay

≥97% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 5 mg/mL
water: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C23H32N4O8/c1-12(2)20(23(35)27-21(33)13(3)24-16(11-28)10-19(31)32)26-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,24,30H,9-10H2,1-4H3,(H,25,29)(H,26,34)(H,31,32)(H,27,33,35)/t13-,16-,18-,20-/m0/s1

InChI key

KQCBPHUOVBKBPQ-SJVNDZIOSA-N

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Caspase-1 Inhibitor I The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

400010

Caspase-1 Inhibitor I

Caspase-3 Inhibitor I The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

235420

Caspase-3 Inhibitor I

Caspase-4 Inhibitor I The Caspase-4 Inhibitor I, also referenced under CAS 402832-01-3, controls the biological activity of Caspase-4. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

218755

Caspase-4 Inhibitor I

Caspase-1 Inhibitor II The Caspase-1 Inhibitor II, also referenced under CAS 178603-78-6, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

400012

Caspase-1 Inhibitor II

assay

≥97% (HPLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

powder

form

solid

form

lyophilized solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

color

white

color

white

color

white

color

white

solubility

DMSO: 5 mg/mL, water: soluble

solubility

DMSO: 5 mg/mL, water: soluble

solubility

water: 1 mg/mL

solubility

DMSO: 5 mg/mL

General description

A potent, specific, and reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. ICE inhibitor I is a potent, specific, and reversible inhibitor of ICE (Ki = 200 pM for human recombinant ICE). Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.

Biochem/physiol Actions

Cell permeable: no
Primary Target
caspase-1, human recombinant
Product does not compete with ATP.
Reversible: yes
Target Ki: 200 pM for human recombinant caspase-1

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Tyr-Val-Ala-Asp-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Los, M., et al. 1995. Nature375, 81.
Walker, N.P.C., et al. 1994. Cell78, 343.
Wilson, K.P., et al. 1994. Nature370, 270.
Thornberry, N.A., et al. 1992. Nature356, 768.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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