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  • 400015
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400015

Sigma-Aldrich

Caspase-1 Inhibitor IV

The Caspase-1 Inhibitor IV, also referenced under CAS 154674-81-4, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

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Synonym(s):
Caspase-1 Inhibitor IV, ICE Inhibitor IV, Ac-YVAD-AOM
Empirical Formula (Hill Notation):
C33H42N4O10
CAS Number:
154674-81-4
Molecular Weight:
654.71

Quality Level

100

Assay

≥96% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

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218735400012218745
Caspase-1 Inhibitor IV The Caspase-1 Inhibitor IV, also referenced under CAS 154674-81-4, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

400015

Caspase-1 Inhibitor IV

Caspase Inhibitor II The Caspase Inhibitor II, also referenced under CAS 147837-52-3, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

218735

Caspase Inhibitor II

Caspase-1 Inhibitor II The Caspase-1 Inhibitor II, also referenced under CAS 178603-78-6, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

400012

Caspase-1 Inhibitor II

Caspase Inhibitor III The Caspase Inhibitor III, also referenced under CAS 634911-80-1, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

218745

Caspase Inhibitor III

assay

≥96% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

-

form

solid

form

solid

form

solid

form

semisolid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated

color

white

color

white

color

white

color

off-white

solubility

DMSO: 5 mg/mL

solubility

DMSO: 150 mg/mL

solubility

DMSO: 5 mg/mL

solubility

DMSO: 5 mg/mL

General description

A highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
Highly selective, competitive and irreversible inhibitor of caspase-1 and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-1
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)

Reconstitution

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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