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Key Documents

400083

Sigma-Aldrich

HIF-1 Inhibitor

Synonym(s):

HIF-1 Inhibitor

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About This Item

Linear Formula:
C26H29NO5
CAS Number:
934593-90-5
MDL number:
MFCD09907563
UNSPSC Code:
12352200
NACRES:
NA.28
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form

(Light beige powder)

Quality Level

100

storage condition

OK to freeze

solubility

soluble (DMSO (10 mg/ml))

storage temp.

2-8°C

SMILES string

N(c5c(ccc(c5)C(=O)OC)O)C(=O)COc1ccc(cc1)C32CC4CC(C3)CC(C2)C4

InChI

1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29)

InChI key

BJRPPNOJYFZSLY-UHFFFAOYSA-N

General description

A cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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