The IKK-2 Inhibitor XI, also referenced under CAS 354810-80-3, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
A cell-permeable thiophenecarboxamide-ureido compound that acts as a potent, ATP-binding pocket-targeting inhibitor of IKK-2 (IC50 = 25 nM), while affecting IKK-1 and JNK1 only at much higher concentrations (IC50 = 1.0 and 1.6 µM, respectively). Shown to reduce LPS-induced TNF-α production in PBMCs (IC50 = 250 nM) and exhibit oral availability with good pharmacokinetic in rats in vivo.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Other Notes
Baxter, A., et al. 2004. Bioorg. Med. Chem. Lett.14, 2817.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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