407621

Sigma-Aldrich

IL-2Rα Antagonist - CAS 1217448-66-2 - Calbiochem

The IL-2Rα Antagonist, also referenced under CAS 1217448-66-2, controls the biological activity of IL-2Rα.

Synonym(s):
(R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550, IL-2Rα Antagonist - CAS 1217448-66-2 - Calbiochem
Empirical Formula (Hill Notation):
C26H30N4O3 · xC2HF3O2
CAS Number:
Molecular Weight:
446.54 (free base basis)
Pricing and availability is not currently available.

storage conditions

+2C to +8C

Quality Level

assay

≥95% (HPLC)

form

solid

mfr. no.

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

ethanol: 2 mg/mL
DMSO: 28 mg/mL

shipped in

ambient

General description

A non-peptidyl acylphenylalanine compound that binds to IL-2 and acts as a competitive inhibitor of the IL-2/IL-2Rα interaction (IC50 = 3 µM).

Packaging

5 mg in Plastic ampoule
Packaged under inert gas

Biochem/physiol Actions

Product does not compete with ATP.
Reversible: no
Target IC50: 3 µM against IL-2/IL-2Rα interaction
Primary Target
Inhibitor of the IL-2/IL-2Rα interaction
Cell permeable: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Emerson, S.D., et al. 2003. Protein Science12, 811.
Tilley, J.W., et al. 1997. J. Am. Chem. Soc.119, 7589.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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