419800

PARP Inhibitor IV, IQD

The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(s): PARP Inhibitor IV, IQD, 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinoline, 1,5-Isoquinolinediol
• Empirical Formula (Hill Notation): C₉H₇NO₂
• CAS Number: 5154-02-9
• Molecular Weight: 161.16
• MDL number: MFCD00006900

Properties

• Quality Level: 100
• Assay: ≥98% (NMR)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white to off-white
• solubility: DMSO: 30 mg/mL; 0.1 M NaOH: 5 mg/mL; methanol: 8 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
• InChI key: LFUJIPVWTMGYDG-UHFFFAOYSA-N

Description

General description

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

A potent, cell-permeable inhibitor of poly(ADP-ribose) polymerase (PARS; IC₅₀ = 390 nM). Blocks nitric oxide-induced neuronal toxicity.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Poly(ADP-ribose) polymerase (PARS)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 390 nM against poly(ADP-ribose) polymerase (PARS)

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kamoshima, W., et al. 1997. Neurochem. Int. 30, 305.
Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14.
Zhang, J., et al. 1994. Science 263, 687.
Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3