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420122

Sigma-Aldrich

JAK3 Inhibitor V

The JAK3 Inhibitor V, also referenced under CAS 932258, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

JAK3 Inhibitor V, (2-Naphthylvinyl Ketone), ZM 449829

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About This Item

Empirical Formula (Hill Notation):
C13H10O
CAS Number:
Molecular Weight:
182.22
UNSPSC Code:
12352200

Quality Level

assay

≥98% (HPLC)

form

waxy solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

DMSO: 10 mg/mL
ethanol: 10 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2

InChI key

FOTCGZPFSUWZBN-UHFFFAOYSA-N

General description

A breakdown product of JAK3 Inhibitor IV (Cat. No. 420121) with similar inhibitory potency (pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.
A breakdown product of JAK3 Inhibitor-IV (Cat. No. 420121) with similar inhibitory potency (pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no
pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO; reconstitute just prior to use.

Other Notes

Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett.10, 575.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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