420127

Sigma-Aldrich

InSolution Jasplakinolide, Jaspis johnstoni - Calbiochem

InSolution Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a 1 mM solution of Jasplakinolide, Jaspis johnstoni in DMSO. Acts as a potent inducer of actin polymerization and stabilization.

Synonym(s):
InSolution Jasplakinolide, Jaspis johnstoni - Calbiochem
Empirical Formula (Hill Notation):
C36H45BrN4O6
Molecular Weight:
709.67
Pricing and availability is not currently available.

storage conditions

-20C

Quality Level

assay

≥90% (HPLC)

form

liquid

mfr. no.

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

shipped in

wet ice

General description

A cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide, isolated from the marine sponge Jaspis johnstoni, is a potent inducer of actin polymerization and stabilization in vitro. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays fungicidal, insecticidal, and anticancer properties.

Packaging

50 μg in Plastic ampoule
Packaged under inert gas

Biochem/physiol Actions

Primary Target
F-actin
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Kd = 15 nM for actin binding

Warning

Toxicity: Harmful (C)

Physical form

A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420107) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Rosado, J.A., et al. 2000. J. Biol. Chem.275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem.274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst.87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem.269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother.32, 1154.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany

WGK 1

Flash Point(F)

188.6 °F - (Dimethylsulfoxide)

Flash Point(C)

87 °C - (Dimethylsulfoxide)

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