420311

Kanamycin Sulfate, Streptomyces kanamyceticus

An aminoglycoside antibiotic effective against Gram-positive and Gram-negative organisms.

• Synonym(s): Kanamycin Sulfate, Streptomyces kanamyceticus, Kamycin
• Empirical Formula (Hill Notation): C₁₈H₃₆N₄O₁₁ · xH₂SO₄
• CAS Number: 25389-94-0
• Molecular Weight: 484.50 (free base basis)
• UNSPSC Code: 51281654

Properties

• Product Name: Kanamycin Sulfate, Streptomyces kanamyceticus, An aminoglycoside antibiotic effective against Gram-positive and Gram-negative organisms.
• InChI key: OOYGSFOGFJDDHP-KMCOLRRFSA-N
• InChI: 1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: water: 10 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• Quality Level: 100

Description

Biochem/physiol Actions

Primary Target
protein biosynthesis

General description

Contains more than 98% kanamycin A. An aminoglycoside antibiotic affective against gram-positive and gram-negative organisms. Inhibitor of protein biosynthesis that acts on the 70S ribosome, causing misreading of the genetic code. May cause renal damage and ototoxicity.

Potency: ≥750 µg/mg

Other Notes

Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1 (Ausubel, F.M., et al., eds.) John Wiley & Sons, New York.
Kahn, R.W., et al. 1993. Proc. Natl. Acad. Sci. USA90, 9295.
Cardon, G.H., et al. 1993. Plant J.3, 773.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, New York. p.1.6, A.6.
Korzybyski, T., et al. 1978. In Antibiotics, Origin, Nature, and Properties1, 690.
Stiffler, P.W., et al. 1974. Antimicrob. Agents Chemother.6, 516.
Umezawa, S., et al. 1968. J. Antibiot.21, 367.

Preparation Note

Following reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H360D
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 2