Anti-LRP, Light Chain Mouse mAb (5A6)

Name: Anti-LRP, Light Chain Mouse mAb (5A6)
Brand: MM
Price: 490 USD

liquid, clone 5A6, Calbiochem^®

Synonym(s):

Anti-Low Density Lipoprotein Receptor-Related Protein

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100 μG

$490.00

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About This Item

NACRES:

NA.43

UNSPSC Code:

12352203

Clone:

5A6, monoclonal

Species reactivity:

rabbit, mouse, human

Application:

—

Citations:

Key Documents

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biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

5A6, monoclonal

form

liquid

does not contain

preservative

species reactivity

rabbit, mouse, human

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

dilution

(Frozen Sections (1-5 µg/mL)
Immunoblotting (1-5 µg/mL)
Paraffin Sections (1-5 µg/mL, )

isotype

IgG2

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... LRP1(4035)

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This Item	MABN1796	428017	SAB1300316
Sigma-Aldrich 438192 Anti-LRP, Light Chain Mouse mAb (5A6)	Sigma-Aldrich MABN1796 Anti-LRP1 Antibody, 85 kDa subunit Antibody, clone 6F8	Sigma-Aldrich 428017 Anti-Lamp1 Mouse mAb (LY1C6)	$Anti-LRP3 (C-term) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich SAB1300316 Anti-LRP3 (C-term) antibody produced in rabbit
biological source mouse	biological source mouse	biological source mouse	biological source rabbit
species reactivity rabbit, mouse, human	species reactivity human, mouse	species reactivity rat	species reactivity human
antibody form purified antibody	antibody form purified immunoglobulin	antibody form purified antibody	antibody form IgG fraction of antiserum
Gene Information human ... LRP1(4035)	Gene Information human ... LRP1(4035)	Gene Information rat ... Lamp1(25328)	Gene Information human ... LRP3(4037)
clone 5A6, monoclonal	clone 6F8, monoclonal	clone LY1C6, monoclonal	clone polyclonal
isotype IgG2	isotype IgG1κ	isotype IgG1	isotype -

General description

Purified mouse monoclonal antibody. Recognizes the ~85 kDa LRP light chain protein under non-reducing conditions.

Recognizes the ~85 kDa LRP protein.

This Anti-LRP, Light Chain Mouse mAb (5A6) is validated for use in Frozen Sections, Immunoblotting, Paraffin Sections for the detection of LRP, Light Chain.

Immunogen

Human

purified, human placenta LRP

Application

Frozen Sections (1-5 µg/ml)

Immunoblotting (1-5 µg/ml)

Paraffin Sections (1-5 µg/ml, see application references)

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 100 mM NaCl, 50 mM sodium phosphate, 1 mM EDTA, pH 6.6.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Mikhailenko, I., et al. 2001. J. Biol. Chem.276, 39484.
Rebeck, W.G., et al. 2001. Mol. Brain Res.87, 238.
Coukos, G., et al. 1994. Am. J. Pathol.144, 383.
Daugherty, A., and Rateri, D.L. 1994. Arterioscler Thromb.14, 2017.
Strickland, D.K., et al. 1990. J. Biol. Chem.265, 17401.

Variables associated with assay conditions will dictate the proper working dilution.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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We previously reported that anti-amyloid-beta (Aβ) single-chain antibody (scFv59) brain delivery via recombinant adeno-associated virus (rAAV) was effective in reducing cerebral Aβ load in an Alzheimer's disease (AD) mouse model without inducing inflammation. Here, we investigated the prophylactic effects and

A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain.

Abhay P Sagare et al.

The Journal of biological chemistry, 288(21), 15154-15166 (2013-04-13)

Soluble low density lipoprotein receptor-related protein-1 (sLRP1) binds ~70% of amyloid β-peptide (Aβ) in human plasma. In Alzheimer disease (AD) and individuals with mild cognitive impairment converting to AD, plasma sLRP1 levels are reduced and sLRP1 is oxidized, which results

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(1), 117-128 (2011-09-29)

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