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440205-M

Millipore

LY 83583 - CAS 91300-60-6 - Calbiochem

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM).

Synonym(s):
6-Anilino-5,8-quinolinequinone, LY 83583 - CAS 91300-60-6 - Calbiochem
Empirical Formula (Hill Notation):
C15H10N2O2
CAS Number:
Molecular Weight:
250.25
MDL number:

Quality Level

assay

≥98% (TLC and HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

red-purple

solubility

ethanol: 3 mg/mL
acetone: soluble

storage temp.

2-8°C

InChI

1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H

InChI key

GXIJYWUWLNHKNW-UHFFFAOYSA-N

General description

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.
A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells.

Biochem/physiol Actions

Target IC50: 2 µM against soluble guanylate cyclase
Primary Target
soluble guanylate cyclase

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.

Other Notes

Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
Pandol, S.J., et al. 1990. J. Biol. Chem.265, 12846.
Light, D.B., et al. 1989. Science 243, 383.
Mulsch, A. 1988. J. Pharmacol. Exp. Ther.247, 283.
Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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