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441251

α2-Macroglobulin, Human Plasma

A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases.

Synonym(s):

α2M, α2MG

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$160.00

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$1,020.00

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About This Item

NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized
Quality level:
100
Storage condition:
OK to freeze

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assay

≥95% (SDS-PAGE)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

aqueous buffer: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

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This Item
178221178196M6159
α2-Macroglobulin, Human Plasma A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases.

Sigma-Aldrich

441251

α2-Macroglobulin, Human Plasma

α2-Antiplasmin, Human Plasma A 452-amino acid glycoprotein present in plasma at about 70 µg/ml.

Sigma-Aldrich

178221

α2-Antiplasmin, Human Plasma

α1-Antichymotrypsin, Human Plasma Acute-phase protein present at ~45 mg/100 ml in plasma.

Sigma-Aldrich

178196

α1-Antichymotrypsin, Human Plasma

α2-Macroglobulin from human plasma BioUltra, ≥98% (SDS-PAGE)

Sigma-Aldrich

M6159

α2-Macroglobulin from human plasma

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

form

lyophilized

form

solid

form

solid

form

lyophilized powder

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

aqueous buffer: soluble

solubility

-

solubility

aqueous buffer: soluble

solubility

water: soluble 10 mg protein/mL, clear, colorless

Biochem/physiol Actions

Cell permeable: no
Primary Target
broad range protease
Product does not compete with ATP.
Reversible: no

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Standard Handling (A)

General description

A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α2M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.

Other Notes

Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.
Lysiak, J.J., et al. 1995. J. Biol. Chem.270, 21919.
Boisset, N., et al. 1992. J. Struct. Biol.108, 221.
Barrett, A.J. 1980. Methods Enzymol.80, 737.

Physical form

Lyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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