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444144

Sigma-Aldrich

MDM2 Antagonist II, NSC 66811

The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.

Synonym(s):

MDM2 Antagonist II, NSC 66811, 7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II

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About This Item

CAS Number:
UNSPSC Code:
12352200

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 10 mg/mL

storage temp.

2-8°C

InChI

1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3

InChI key

WEENRMPCSWFMTE-UHFFFAOYSA-N

General description

A cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (Ki = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.
The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
MDM2
Product does not compete with ATP.
Target Ki: 120 nM against MDM2

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lu, Y., et al. 2006. J. Med. Chem.49, 3759.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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