444144

MDM2 Antagonist II, NSC 66811

The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.

• Synonym(s): MDM2 Antagonist II, NSC 66811, 7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II
• CAS Number: 6964-62-1
• UNSPSC Code: 12352200

Properties

• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 10 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
• InChI key: WEENRMPCSWFMTE-UHFFFAOYSA-N

Description

General description

A cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (K_i = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.

The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
MDM2

Product does not compete with ATP.

Target K_i: 120 nM against MDM2

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lu, Y., et al. 2006. J. Med. Chem.49, 3759.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable