444241

MMP-2

≥95% (HPLC), MMP-2 and MMP-9 inhibitor, solid

• Synonym(s): MMP-2/MMP-9 Inhibitor I, (2R)-2-[(4-Biphenylylsulfonyl)amino]-3-phenylpropionic Acid
• Empirical Formula (Hill Notation): C₂₁H₁₉NO₄S
• CAS Number: 193807-58-8
• Molecular Weight: 381.44
• MDL number: MFCD16660190
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Properties

• Product Name: MMP-2/MMP-9 Inhibitor I, The MMP-2/MMP-9 Inhibitor I, also referenced under CAS 193807-58-8, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 200 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A potent inhibitor of MMP-2 (IC₅₀ = 310 nM) and MMP-9 (IC₅₀ = 240 nM). Orally active in animal models of tumor growth and metastasis.

A potent inhibitor of MMP-2 (gelatinase A; IC₅₀ = 310 nM) and MMP-9 (gelatinase B; IC₅₀ = 240 nM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
MMP-2, MMP-9

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 310 nM and 240 nM against MMP-2 and MMP-9

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Tamura, Y., et al. 1998. J. Med. Chem.41, 640.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable