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  • 444264
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444264

Sigma-Aldrich

MMP Inhibitor III

The MMP Inhibitor III, also referenced under CAS 927827-98-3, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

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Synonym(s):
MMP Inhibitor III
Empirical Formula (Hill Notation):
C19H29N3O4
CAS Number:
927827-98-3
Molecular Weight:
363.45

Quality Level

100

Assay

≥90% (TLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

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444247444288444225
MMP Inhibitor III The MMP Inhibitor III, also referenced under CAS 927827-98-3, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444264

MMP Inhibitor III

MMP Inhibitor II The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444247

MMP Inhibitor II

MMP-2 Inhibitor III The MMP-2 Inhibitor III, also referenced under CAS 704888-90-4, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444288

MMP-2 Inhibitor III

MMP-3 Inhibitor II The MMP-3 Inhibitor II, also referenced under CAS 161314-17-6, controls the biological activity of MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444225

MMP-3 Inhibitor II

assay

≥90% (TLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (TLC)

form

lyophilized solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

storage condition

OK to freeze

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

color

off-white

color

off-white

color

white

color

white

solubility

DMSO: 5 mg/mL

solubility

DMSO: 100 mg/mL

solubility

methanol: 100 mg/mL, DMSO: 200 mg/mL

solubility

DMSO: 30 mg/mL, ethanol: 8 mg/mL

General description

A homophenylalanine-hydroxamic acid based broad-spectrum cell-permeable, reversible inhibitor of matrix metalloproteinases (supplied as a racemic mixture). Inhibits MMP-1 (IC50 = 7.4 nM), MMP-2 (IC50 = 2.3 nM), MMP-3 (IC50 = 135 nM), MMP-7 (IC50 = 10-100 nM), and MMP-13 (IC50 = 1-10 nM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
MMP-1
Product does not compete with ATP.
Reversible: yes
Target IC50: 7.4 nM, 2.3 nM, 135 nM, 10-100 nM, 1-10 nM, against MMP-1, MMP-2, MMP-3, MMP-7, and MMP-13, respectively

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months (-20°C).

Other Notes

Covington, M.D., et al. 2006, Am. J. Physiol. Renal. Physiol.290, F43.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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