MMP-7, Active, Human, Recombinant, E. coli

Name: MMP-7, Active, Human, Recombinant, <i>E. coli</i>
Brand: MM

Synonym(s):

Matrilysin, rhMMP-7, PUMP-1

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About This Item

EC Number:

3.4.24.23 (BRENDA, IUBMB)

NACRES:

NA.77

UNSPSC Code:

12352202

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Key Documents

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form

liquid

specific activity

≥3000 units/mg protein

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

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This Item	538540	475935	444217
Sigma-Aldrich 444270 MMP-7, Active, Human, Recombinant, E. coli	Sigma-Aldrich 538540 MMP-7, Proenzyme, Human, Recombinant, E. coli	Sigma-Aldrich 475935 MT1-MMP, Catalytic Domain, Human, Recombinant, E. coli	Sigma-Aldrich 444217 MMP-3, Catalytic Domain, Human, Recombinant, E. coli
specific activity ≥3000 units/mg protein	specific activity ≥1400 units/mg protein (after activation)	specific activity ≥140 mU/mg protein	specific activity ≥1250 mU/mg protein
form liquid	form liquid	form liquid	form liquid
storage temp. −70°C	storage temp. −70°C	storage temp. −70°C	storage temp. −70°C
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in wet ice
storage condition OK to freeze, avoid repeated freeze/thaw cycles	storage condition OK to freeze, avoid repeated freeze/thaw cycles	storage condition OK to freeze, avoid repeated freeze/thaw cycles	storage condition OK to freeze, avoid repeated freeze/thaw cycles
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®

Disclaimer

Toxicity: Standard Handling (A)

General description

Recombinant, human MMP-7 expressed in E. coli. MMP-7, the smallest member of the matrix metalloproteinase family that can degrade a wide range of gelatins, proteoglycans, and glycoproteins of the matrix and can activate several other MMPs.

Other Notes

Kivelä-Rajamäki, M., et al. 2003. J. Periodont. Res.38, 583.
Woessner, J.F. 1995. Methods Enzymol. 248, 485.
Crabbe, T., et al. 1992. Biochemistry 31, 8500.

One unit is defined as the amount of enzyme that will digest 1.0 µg AZOCOLL Substrate (Cat. No. 194933) per min at 37°C, pH 7.5.

Physical form

In 150 mM NaCl, 10 mM HEPES, 5 mM CaCl₂, pH 7.4.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Reconstitution of hematopoiesis following transplantation into neonatal mice.

Scott A Johnson et al.

Methods in molecular medicine, 105, 95-106 (2004-10-20)

The primary sites of hematopoiesis change during murine ontogeny. The first blood cells emerge in two waves in the yolk sac; primitive erythroblasts, megakaryocytes, and macrophages emerge on embryonic d (E) 7.0, whereas definitive progenitor cells appear as clusters within

Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation.

Katherine Conant et al.

Journal of neuroinflammation, 14(1), 56-56 (2017-03-18)

Matrix metalloproteinases (MMPs) are a family of enzymes that are typically released from intracellular stores to act on specific extracellular substrates. MMP expression and activity can be increased in a neuronal activity-dependent manner, and further increased in response to tissue

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