444278-M

MMP-9 Inhibitor I

≥93% (HPLC), solid, MMP-9 inhibitor, Calbiochem^®

• Synonym(s): MMP-9 Inhibitor I
• Empirical Formula (Hill Notation): C₂₇H₃₃N₃O₅S
• CAS Number: 1177749-58-4
• Molecular Weight: 511.63
• MDL number: MFCD22581508
• UNSPSC Code: 12352200

Properties

• Product Name: MMP-9 Inhibitor I, MMP-9 Inhibitor I, CAS 1177749-58-4, is a cell-permeable, potent, and reversible MMP-9 Inhibitor (IC₅₀ = 5 nM). At high concentration inhibits MMP-1 (IC₅₀ = 1.05 µM) & MMP-13 (IC₅₀ = 113 nM).
• Quality Level: 100
• assay: ≥93% (HPLC)
• form: solid
• potency: 5 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 10 mg/mL
• storage temp.: −20°C
• SMILES string: [S](=O)(N(Cc3ccccc3)c2c(cc(cc2C(=O)NO)CN(CC)CC)C)Oc1ccc(cc1)OC
• InChI: 1S/C27H33N3O5S/c1-5-29(6-2)18-22-16-20(3)26(25(17-22)27(31)28-32)30(19-21-10-8-7-9-11-21)36(33)35-24-14-12-23(34-4)13-15-24/h7-17,32H,5-6,18-19H2,1-4H3,(H,28,31)
• InChI key: OIYCVCCJVZCTIX-UHFFFAOYSA-N

Description

General description

A cell-permeable, potent, selective, and reversible MMP-9 Inhibitor (IC₅₀ = 5 nM). Inhibits MMP-1 (IC₅₀ = 1.05 µM) and MMP-13 (IC₅₀ = 113 nM) only at much higher concentrations.

Biochem/physiol Actions

Primary Target
MMP-9

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Levin, J.I., et al. 2001. Bioorg. Med. Chem. Lett.11, 2189.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable