475825
mitoNEET Inhibitor NL-1, Thiazolidinedione
The mitoNEET Inhibitor NL-1, Thiazolidinedione controls the biological activity of mitoNEET.
Synonym(s):
mitoNEET Inhibitor NL-1, Thiazolidinedione, 5-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-hydroxythiazol-2(5H)-one
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About This Item
Empirical Formula (Hill Notation):
C18H25NO3S
Molecular Weight:
335.46
UNSPSC Code:
12352200
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
yellow
solubility
DMSO: 100 mg/mL, clear, pale yellow
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable, thiazolidinedione (TZD) that acts as an inhibitor of MitoNEET (IC50 = 0.9 µM) in competition with rosiglitazone and pioglitazone, in liver mitochondrial suspensions. In pharmacological studies, it was found to alter isolated mitochondrial complex I respiration with an IC50 of 2.4 µM and inhibited State III respiration up to 45%. Furthermore, this compound (6-25 µM) is shown to dose-dependently reduce lactate-dehydrogenase release in SH-SY5Y cultures, leading to a 40% decrease in rotenone-induced cell-death.
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Geldenhuys, W.J., et al. 2009. Bioorg Med Chem Lett.3, 819.
Giles, R.G., et al. 2000. Tetrahedron56, 4531.
Giles, R.G., et al. 2000. Tetrahedron56, 4531.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Seunghee Lee et al.
Cell death & disease, 13(2), 127-127 (2022-02-10)
MitoNEET (mitochondrial protein containing Asn-Glu-Glu-Thr (NEET) sequence) is a 2Fe-2S cluster-containing integral membrane protein that resides in the mitochondrial outer membrane and participates in a redox-sensitive signaling and Fe-S cluster transfer. Thus, mitoNEET is a key regulator of mitochondrial oxidative
Aitor Martinez et al.
Molecular neurodegeneration, 19(1), 12-12 (2024-01-26)
Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease (PD). Functional analysis of genes linked to PD have revealed that the E3 ligase Parkin and the
Kamalakannan Vijayan et al.
Cell chemical biology, 29(9), 1419-1433 (2022-06-24)
Prior to initiating symptomatic malaria, a single Plasmodium sporozoite infects a hepatocyte and develops into thousands of merozoites, in part by scavenging host resources, likely delivered by vesicles. Here, we demonstrate that host microtubules (MTs) dynamically reorganize around the developing
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