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475840

Sigma-Aldrich

Milrinone

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 300 nM).

Synonym(s):
Milrinone, 1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile
Empirical Formula (Hill Notation):
C12H9N3O
CAS Number:
Molecular Weight:
211.22
MDL number:

Quality Level

Assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 20 mg/mL
ethanol: 3 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

InChI key

PZRHRDRVRGEVNW-UHFFFAOYSA-N

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This Item
M46591443908PHR2515
Milrinone A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 300 nM).

Sigma-Aldrich

475840

Milrinone

Milrinone ≥97% (TLC), powder

Sigma-Aldrich

M4659

Milrinone

Milrinone United States Pharmacopeia (USP) Reference Standard

USP

1443908

Milrinone

Milrinone Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2515

Milrinone

assay

≥99% (HPLC)

assay

≥97% (TLC)

assay

-

assay

-

form

solid

form

powder

form

-

form

powder

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

USP

manufacturer/tradename

-

storage condition

OK to freeze

storage condition

-

storage condition

-

storage condition

-

color

white

color

off-white

color

-

color

-

solubility

DMSO: 20 mg/mL, ethanol: 3 mg/mL

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

-

solubility

-

General description

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50 = 300 nM). Has positive chronotropic, ionotropic, and vasodilatory effects on the heart.
A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PDE 3
Product does not compete with ATP.
Reversible: no
Target IC50: 300 nM against PDE III

Warning

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Bailey, J.M., et al. 1994. Anesthesiology 81, 616.
Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol.20, 705.
Lindgren, S.H., et al. 1990. Acta. Phys. Scand.140, 209.
Harrison, S.A., et al. 1986. Mol. Pharmacol.29, 506.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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