Cell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O2– • (rate constant ~4 x 107 M-1 s-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O2• oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Other Notes
Izbicka, E., et al. 1999. Cancer Res.59, 639. Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053. Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20. Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271. Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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