A cell-permeable quinoxaline compound that is shown to induce neuronal differentiation in PC12 and rat MSC (mesenchymal stem cell) cultures with high efficiency (>95%; 20 µM for 48 h) as determined by Nissl staining, expressions of neuronal markers and genes (β-III tubulin, NSE, Chrna2, Chrnb2, Chrm4, Foxo2, Sizn 1), as well as by whole-cell electrophysiology measurements, without any concomitant astroglial differentiation induction as indicated by the absence of GFAP (glial fibrillary acidic protein) expression.
Toxicity: Standard Handling (A)
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Kim, N.R., et al. 2009. J. Med. Chem.52, 7931.
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