480747

Sigma-Aldrich

Neurogenesis Inducer V, KHS101 - Calbiochem

A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2).

Synonym(s):
N⁴-Isobutyl-N²-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine, Neurogenesis Inducer V, KHS101 - Calbiochem
Empirical Formula (Hill Notation):
C18H21N5S
Molecular Weight:
339.46
Pricing and availability is not currently available.

storage conditions

+2C to +8C

Quality Level

assay

≥95% (HPLC)

form

resin (Sticky)

mfr. no.

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 100 mg/mL

shipped in

wet ice

General description

A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2). Shown to significantly induce neuronal differentiation of cultured rat hippocampal NPCs (neural progenitor cells; EC50 ~ 1 µM) and in adult rats (6 mg/kg, s.c.) and suppress proliferation.

Packaging

10 mg in Glass bottle
Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Wurdak, H., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16542

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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