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481480

Sigma-Aldrich

NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

Synonym(s):
NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem
Empirical Formula (Hill Notation):
C129H230N36O29S
Molecular Weight:
2781.50
Pricing and availability is not currently available.

storage conditions

-20C

Quality Level

assay

≥97% (HPLC)

form

lyophilized

mfr. no.

Calbiochem®

storage condition

OK to freeze
desiccated

solubility

water: 5 mg/mL

shipped in

ambient

General description

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.
Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The peptide N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, inhibition of NF-κB nuclear translocation is maximally inhibited at 18 µM.
Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.

Packaging

500 μg in Plastic ampoule
1 mg in Plastic ampoule

Biochem/physiol Actions

Product does not compete with ATP.
Cell permeable: yes
Primary Target
translocation of the NF-κB active complex into the nucleus

Warning

Toxicity: Standard Handling (A)

Sequence

H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Other Notes

Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

Legal Information

Sold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Certificate of Analysis
Certificate of Origin

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