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  • 487910M
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487910-M

Millipore

(±)-S-Nitroso-N-acetylpenicillamine

Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM).

All Photos(1)
Synonym(s):
(±)-S-Nitroso-N-acetylpenicillamine, SNAP
Empirical Formula (Hill Notation):
C7H12N2O4S
CAS Number:
79032-48-7
Molecular Weight:
220.25

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale green

solubility

DMSO: 25 mg/mL
ethanol: 25 mg/mL
methanol: soluble

storage temp.

−20°C

InChI

1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)

InChI key

ZIIQCSMRQKCOCT-UHFFFAOYSA-N

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PH006326400600PH000678
(±)-S-Nitroso-N-acetylpenicillamine Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM).

Millipore

487910-M

(±)-S-Nitroso-N-acetylpenicillamine

Sigma-Aldrich

Sigma-Aldrich

PH006326

N-Acetyl-N-methyl-2-nitrobenzenesulfonamide

L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase compared to other arginine analogs such as L-NAME and L-NMMA.

Sigma-Aldrich

400600

L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride

Sigma-Aldrich

Sigma-Aldrich

PH000678

(2S)-(Acetylamino)(4-nitrophenyl)ethanoic acid

assay

≥95% (HPLC)

assay

-

assay

≥98% (TLC)

assay

-

form

solid

form

-

form

solid

form

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

-

color

pale green

color

-

color

white

color

-

solubility

DMSO: 25 mg/mL, ethanol: 25 mg/mL, methanol: soluble

solubility

-

solubility

water: 1 mg/mL

solubility

-

General description

Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.

Biochem/physiol Actions

EC50 = 130 nM in relaxation of isolated bovine coronary artery rings
Primary Target
Nitric oxide donor

Warning

Toxicity: Irritant (B)

Reconstitution

SNAP evolves NO immediately upon solubilization; reconstitute just prior to use.

Other Notes

Nishio, E., et al. 1996. Biochem. Biophys. Res. Commun.221, 163.
Askew, S.C., et al. 1995. Bioorg. Med. Chem.3, 1.
Fehsel, K., et al. 1995. J. Immunol.155, 2858.
Gopalkrishna, R., et al. 1993. J. Biol. Chem.268, 27180.
Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther.248, 762.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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