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487928

Sigma-Aldrich

Nocodazole

Inhibitor of mitosis.

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Synonym(s):
Nocodazole, R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
Empirical Formula (Hill Notation):
C14H11N3O3S
CAS Number:
Molecular Weight:
301.32
MDL number:
NACRES:
NA.77

Quality Level

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

pale yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChI key

KYRVNWMVYQXFEU-UHFFFAOYSA-N

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This Item
M1404SML1665361559
Nocodazole Inhibitor of mitosis.

487928

Nocodazole

Nocodazole ≥99% (TLC), powder

M1404

Nocodazole

Nocodazole Ready Made Solution 5 mg/mL, DMSO solution

SML1665

Nocodazole Ready Made Solution

GSK-3 Inhibitor XVI GSK-3 Inhibitor XVI - CAS 252917-06-9, is a cell-permeable, potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC₅₀ = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively).

361559

GSK-3 Inhibitor XVI

assay

≥99% (HPLC)

assay

≥99% (TLC)

assay

-

assay

≥97% (HPLC)

Quality Level

100

Quality Level

300

Quality Level

200

Quality Level

200

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

storage temp.

10-30°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL

solubility

DMSO: soluble 10 mg/mL (may require heating), H2O: insoluble

solubility

-

solubility

DMSO: 5 mg/mL

General description

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd<2 µM).
Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Promotes tubulin depolymerization
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.

Other Notes

Park, H., et al. 2011. Chem. Med. Chem.in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard

signalword

Warning

Hazard Classifications

Muta. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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