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490070

Nitric Oxide Synthase, Neuronal Inhibitor I

The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Synonym(s):

Nitric Oxide Synthase, Neuronal Inhibitor I, (4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA

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5 mg
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$697.00

About This Item

Empirical Formula (Hill Notation):
C8H21N7O2 · 3C2HF3O2 · 2H2O
CAS Number:
357965-99-2
Molecular Weight:
625.40
UNSPSC Code:
12352303
NACRES:
NA.77
MDL number:
MFCD05865227
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

$697.00

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Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white to off-white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.[N+](=O)(N\C(=N\CCC[C@H](N)CNCCN)\N)[O-]

InChI

1S/C8H21N7O2.3C2HF3O2/c9-3-5-12-6-7(10)2-1-4-13-8(11)14-15(16)17;3*3-2(4,5)1(6)7/h7,12H,1-6,9-10H2,(H3,11,13,14);3*(H,6,7)/t7-;;;/m0.../s1

InChI key

NYWNMNBIORWOSQ-QTPLPEIMSA-N

General description

A cell-permeable, potent and highly selective inhibitor of neuronal nitric oxide synthase (nNOS); (Ki = 120 nM). Displays >2500-fold and 320-fold selectivity over eNOS and iNOS, respectively.
A cell-permeable, potent, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS) (Ki = 120 nM). Displays >2,500-fold and 192-fold selectivity over eNOS and iNOS, respectively.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
nNOS
Product does not compete with ATP.
Reversible: no
Target Ki: 120 nM against nNOS

Packaging

Packaged under inert gas

Physical form

Supplied as a dihydrate.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hah, J.M., et al. 2001. J. Med. Chem.44, 2667.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Nitric Oxide Synthase, Neuronal Inhibitor I The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Sigma-Aldrich

490070

Nitric Oxide Synthase, Neuronal Inhibitor I

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Sigma-Aldrich

324759

Elastase Inhibitor IV

GSK-3β Inhibitor VIII The GSK-3β Inhibitor VIII, also referenced under CAS 487021-52-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

361549

GSK-3β Inhibitor VIII

MMP-9/MMP-13 Inhibitor I The MMP-9/MMP-13 Inhibitor I, also referenced under CAS 204140-01-2, controls the biological activity of MMP-9/MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Millipore

444252

MMP-9/MMP-13 Inhibitor I

form

solid

form

solid

form

solid

form

solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

water: 1 mg/mL

solubility

DMSO: 10 mg/mL

solubility

DMSO: 5 mg/mL

solubility

methanol: 1 mg/mL, DMSO: 100 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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