Ochratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs).
Ochratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs). OTA is indicated to play a role in down-regulating the expression of protective enzymes against oxidative stress. It is known to accumulate in several tissues of the body but is primarily localized in the kidney where it impairs proximal tubular functions, and thereby causes nephrotoxicity, glucosuria, enzymuria, and a decrease in the transport of para-aminohippuric acid (PAH). It also acts as an immunosuppressant and as a potent teratogen and carcinogen.
1 mg in Glass bottle
Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Anzai, N., et al. 2010. Toxins2, 1381.
Chopra, M., et al. 2010. Cell Biol. Toxicol.26, 239.
Luhe, A., et al. 2002. Tox. Sci.73, 315.
Dirheimer, G., et al. 1991. IARC Swci Publ.115, 171.
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