MilliporeSigma

5.00111

SAFC

Cocarboxylase tetrahydrate

(thiamine pyrophosphate tetrahydrate), EMPROVE® API

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Synonym(s):
Cocarboxylase tetrahydrate
Empirical Formula (Hill Notation):
C12H18N4O7P2S · 4H2O
CAS Number:
Molecular Weight:
496.37
EC Index Number:
205-230-7

Quality Level

product line

EMPROVE® API

form

solid

pH

2.4-3.2 (20 °C, 100 g/L in H2O)

solubility

55 g/L

bulk density

450 kg/m3

application(s)

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-25°C

InChI

1S/C12H18N4O7P2S.4H2O/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;;;;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);4*1H2

InChI key

KLOLNRGPRQYTIW-UHFFFAOYSA-N

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1 of 4

This Item
5.001121.024651.06441
Cocarboxylase tetrahydrate (thiamine pyrophosphate tetrahydrate), EMPROVE® API

5.00111

Cocarboxylase tetrahydrate

Cocarboxylase chloride thiamine diphosphoric acid ester chloride EMPROVE® API

5.00112

Cocarboxylase chloride

Calcium chloride dihydrate EMPROVE® API, Ph. Eur., BP, ChP, JP, USP

1.02465

Calcium chloride dihydrate

Sodium fluoride EMPROVE® API Ph Eur,BP,USP

1.06441

Sodium fluoride

solubility

55 g/L

solubility

220 g/L

solubility

soluble

solubility

-

storage temp.

2-25°C

storage temp.

2-25°C

storage temp.

2-25°C

storage temp.

2-25°C

form

solid

form

solid

form

solid

form

crystals

product line

EMPROVE® API

product line

EMPROVE® API

product line

EMPROVE® API

product line

EMPROVE® API

pH

2.4-3.2 (20 °C, 100 g/L in H2O)

pH

1.0-1.4 (20 °C, 100 g/L in H2O)

pH

4.5-8.5 (20 °C, 50 g/L in H2O)

pH

10.2 (20 °C, 40 g/L in H2O)

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Cocarboxylase tetrahydrate Emprove® API is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Cocarboxylase Tetrahydrate (thiamine diphosphoric acid ester tetrahydrate) Emprove® API is manufactured according to ICH Q7 guidelines. An ASMF is available.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The substance 5.00111 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Ferenc Tóth et al.
Bone, 132, 115214-115214 (2019-12-31)
Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor-β superfamily, it is known to be a factor involved in skeletal development and capable of inducing in vitro osteogenic differentiation of mesenchymal stem cells (MSCs). Dental pulp

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