MilliporeSigma
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5.00112

SAFC

Cocarboxylase chloride

thiamine diphosphoric acid ester chloride EMPROVE® API

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Synonym(s):
Cocarboxylase chloride, Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
CAS Number:
154-87-0
Molecular Weight:
460.77
MDL number:
MFCD00038740
EC Index Number:
205-836-1

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Thiamine phosphoric acid ester chloride dihydrate EMPROVE® API

SAFC

5.00667

Thiamine phosphoric acid ester chloride dihydrate

EMPROVE® API

Thiamine hydrochloride reagent grade, ≥99% (HPLC)

Sigma-Aldrich

T4625

Thiamine hydrochloride

reagent grade, ≥99% (HPLC)

Sodium hydroxide pellets EMPROVE® ESSENTIAL, Ph. Eur., BP, FCC, JP, NF, E 524

SAFC

1.06482

Sodium hydroxide pellets

EMPROVE® ESSENTIAL, Ph. Eur., BP, FCC, JP, NF, E 524

Pyrene-13C16 99 atom % 13C, 98% (CP)

Sigma-Aldrich

729035

Pyrene-13C16

99 atom % 13C, 98% (CP)

Thiamine pyrophosphate ≥95%

Sigma-Aldrich

C8754

Thiamine pyrophosphate

≥95%

L-Cysteine hydrochloride monohydrate EMPROVE® EXPERT, Ph. Eur., JP, USP

SAFC

1.02735

L-Cysteine hydrochloride monohydrate

EMPROVE® EXPERT, Ph. Eur., JP, USP

Sodium hydroxide pellets, EMPROVE® EXPERT, Ph. Eur., BP, JP, NF

SAFC

1.37020

Sodium hydroxide

pellets, EMPROVE® EXPERT, Ph. Eur., BP, JP, NF

Thiamine monophosphate chloride dihydrate

Sigma-Aldrich

T8637

Thiamine monophosphate chloride dihydrate

BIOTIN

SAFC

RES1052B-B7

BIOTIN

L-Alanine EMPROVE® EXPERT Ph Eur,USP

SAFC

1.01700

L-Alanine

EMPROVE® EXPERT Ph Eur,USP

Quality Level

600

product line

EMPROVE® API

form

solid

pH

1.0-1.4 (20 °C, 100 g/L in H2O)

mp

240-244 °C (decomposition)

solubility

220 g/L

bulk density

500 kg/m3

application(s)

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-25°C

InChI

1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);1H

InChI key

YXVCLPJQTZXJLH-UHFFFAOYSA-N

Related Categories

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Cocarboxylase chloride Emprove® API is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Cocarboxylase Chloride (thiamine diphosphoric acid ester chloride) Emprove® API is manufactured according to ICH Q7 guidelines. An ASMF is available.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Elemental Impurities Information

Available by subscription or for a fee

API Information Package

Available by subscription or for a fee

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Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

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