MilliporeSigma

5.00112

SAFC

Cocarboxylase chloride

thiamine diphosphoric acid ester chloride EMPROVE® API

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Synonym(s):
Cocarboxylase chloride, Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
CAS Number:
Molecular Weight:
460.77
MDL number:
EC Index Number:
205-836-1

Quality Level

product line

EMPROVE® API

form

solid

pH

1.0-1.4 (20 °C, 100 g/L in H2O)

mp

240-244 °C (decomposition)

solubility

220 g/L

bulk density

500 kg/m3

application(s)

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-25°C

InChI

1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);1H

InChI key

YXVCLPJQTZXJLH-UHFFFAOYSA-N

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5.001111.024651.02367
vibrant-m

5.00112

Cocarboxylase chloride

vibrant-m

5.00111

Cocarboxylase tetrahydrate

vibrant-m

1.02465

Calcium chloride dihydrate

vibrant-m

1.02367

Magnesium chloride hexahydrate

Quality Level

600

Quality Level

600

Quality Level

600

Quality Level

600

storage temp.

2-25°C

storage temp.

2-25°C

storage temp.

2-25°C

storage temp.

2-25°C

form

solid

form

solid

form

solid

form

solid

product line

EMPROVE® API

product line

EMPROVE® API

product line

EMPROVE® API

product line

EMPROVE® API

pH

1.0-1.4 (20 °C, 100 g/L in H2O)

pH

2.4-3.2 (20 °C, 100 g/L in H2O)

pH

4.5-8.5 (20 °C, 50 g/L in H2O)

pH

4.5-7.0 (20 °C, 50 g/L in H2O)

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Cocarboxylase chloride Emprove® API is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Cocarboxylase Chloride (thiamine diphosphoric acid ester chloride) Emprove® API is manufactured according to ICH Q7 guidelines. An ASMF is available.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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