5.00112

Cocarboxylase chloride

thiamine diphosphoric acid ester chloride EMPROVE^® API

• Synonym(s): Cocarboxylase chloride, Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
• CAS Number: 154-87-0
• Molecular Weight: 460.77
• MDL number: MFCD00038740
• UNSPSC Code: 12352107
• EC Index Number: 205-836-1

Properties

• Quality Level: 600
• product line: EMPROVE^® API
• form: solid
• pH: 1.0-1.4 (20 °C, 100 g/L in H₂O)
• mp: 240-244 °C (decomposition)
• solubility: 220 g/L
• bulk density: 500 kg/m³
• application(s): liquid formulation; pharmaceutical; semi-solid formulation; solid formulation
• storage temp.: 2-25°C
• SMILES string: [P](=O)([O-])(O[P](=O)(O)O)OCCc1[s]c[n+](c1C)Cc2c(nc(nc2)C)N.Cl
• InChI: 1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);1H
• InChI key: YXVCLPJQTZXJLH-UHFFFAOYSA-N

Description

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Cocarboxylase chloride Emprove^® API is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Cocarboxylase Chloride (thiamine diphosphoric acid ester chloride) Emprove^® API is manufactured according to ICH Q7 guidelines. An ASMF is available.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable