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5.05875

Sigma-Aldrich

(+)-Bicuculline

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Synonym(s):
(+)-Bicuculline, GABA A Receptor Antagonist, Bicuculline
Empirical Formula (Hill Notation):
C20H17NO6
CAS Number:
Molecular Weight:
367.35
MDL number:

assay

≥99% (HPLC)

Quality Level

form

solid

potency

740 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: soluble

storage temp.

−20°C

InChI

1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1

InChI key

IYGYMKDQCDOMRE-ZWKOTPCHSA-N

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This Item
14340PHL803715.05986
(+)-Bicuculline

5.05875

(+)-Bicuculline

(+)-Bicuculline ≥97.0% (TLC)

14340

(+)-Bicuculline

(+)-Bicuculline phyproof® Reference Substance

PHL80371

(+)-Bicuculline

SR95531 (Gabazine)

5.05986

SR95531 (Gabazine)

assay

≥99% (HPLC)

assay

≥97.0% (TLC)

assay

≥98.0% (HPLC)

assay

≥98% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

PhytoLab

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: soluble

solubility

-

solubility

-

solubility

water: 25 mM

General description

A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.

Warning

Toxicity: Toxic (F)

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Ueno, S., et al. 1997. J. Neurosci.17, 625.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.
Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol.230, 187.
Robert K.A., et al. 1993. Cardiovasc. Pharmacol.21, 156.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesEnvironment

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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