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(+)-Bicuculline - CAS 485-49-4 - Calbiochem

All Photos(1)

Synonym(s):

(+)-Bicuculline - CAS 485-49-4 - Calbiochem, GABA _A Receptor Antagonist, Bicuculline

Empirical Formula (Hill Notation):

C₂₀H₁₇NO₆

CAS Number:

485-49-4

Molecular Weight:

367.35

MDL number:

MFCD00005006

assay

≥99% (HPLC)

Quality Level

100

form

solid

potency

740 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: soluble

storage temp.

−20°C

InChI

1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1

InChI key

IYGYMKDQCDOMRE-ZWKOTPCHSA-N

General description

A potent allosteric antagonist of vertebrate GABA_A receptors. Blocks GABA_A-induced chloride currents in cultured neurons (IC₅₀ = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.

Warning

Toxicity: Toxic (F)

Other Notes

Ueno, S., et al. 1997. J. Neurosci.17, 625.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.
Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol.230, 187.
Robert K.A., et al. 1993. Cardiovasc. Pharmacol.21, 156.

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Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

GHS06,GHS09

Signal Word

Danger

Hazard Statements

H300 + H310 + H330 - H400

Precautionary Statements

P260 - P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)