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5.05881

(R)-(+)-SKF38393 Hydrochloride

Synonym(s):

(R)-(+)-SKF38393 Hydrochloride, Dopamine D1/D5 Receptor Partial Agonist, (R)-SKF-38393 Hydrochloride, SKF-38393, SKF38393, SKF 38393

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5 MG

$247.00

$247.00

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About This Item

Empirical Formula (Hill Notation):
C16H17NO2 · xHCl
CAS Number:
81702-42-3
Molecular Weight:
255.31 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00055189
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
protect from light

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SMILES string

Cl.N1C[C@@H](c3c(cc(c(c3)O)O)CC1)c2ccccc2

InChI

1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1

InChI key

YEWHJCLOUYPAOH-PFEQFJNWSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 100 mM

storage temp.

−20°C

Quality Level

100

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This Item
5.097085673005.05896
(R)-(+)-SKF38393 Hydrochloride

Sigma-Aldrich

5.05881

(R)-(+)-SKF38393 Hydrochloride

SKF-97541

Sigma-Aldrich

5.09708

SKF-97541

SKF-525A, Hydrochloride Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system.

Sigma-Aldrich

567300

SKF-525A, Hydrochloride

Sumanirole Maleate

Sigma-Aldrich

5.05896

Sumanirole Maleate

form

solid

form

solid

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, protect from light

Biochem/physiol Actions

Primary Target
D₁

Disclaimer

Toxicity: Standard Handling (A)

General description

A benzazepine derivative that acts as a selective Dopamine D1/D5 receptor partial agonist. Examination of the isomers in several in vitro and in vivo tests for both central and peripheral dopaminergic activity revealed that activity resided almost exclusively in the R isomer. The results suggest that the properly oriented 1-phenyl substituent of 1 is important for dopamine-like activity. Reported to have stimulant and anorectic effects.

Other Notes

Trampus, M. et al. 1993. J. Pharmacol.235, 83.
Cooper, S. J. et al. 1990. Psychopharmacol.100, 182.
Dubois, A. et al. 1986. Neurosci.19, 125.
Kaiser, C. C. et al. 1982. J. Med. Chem.25, 697.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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