5.05989

Sigma-Aldrich

Vigabatrin - CAS 68506-86-5 - Calbiochem

Synonym(s):
Vigabatrin - CAS 68506-86-5 - Calbiochem, 4-Amino-5-hexenoic acid, GABA Transaminase Inhibitor, Vigabatrin, γ-Vinyl-GABA, Sabril
Empirical Formula (Hill Notation):
C6H11NO2
CAS Number:
Molecular Weight:
129.16
MDL number:

storage conditions

+2C to +8C

assay

≥99% (HPLC)

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

H2O: 100 mM

storage temp.

2-8°C

General description

A selective, irreversible inhibitor of GABA transaminase with antiepileptic properties. Covalently binds to the active site of GABA tansaminase to inactivate it in a dose-dependent manner and increases extracellular GABA levels in the brain. Rapidly absorbed following oral administration and is shown to inhibit [3H]GABA uptake across the apical membrane of Caco-2 cell monolayers in a concentration-dependent manner (IC50 = 2.9 mM)

Biochem/physiol Actions

Reversible: no
Primary Target
GABA Transaminase

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Abbot, E.L., et al. 2006. Br. J. Pharmacol.147, 298.
Schmid, L., et al. 1996. J. Pharmacol. Exp. Therap.276, 977.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Certificate of Analysis
Certificate of Origin

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