506173
p38 MAP Kinase Inhibitor XI
Synonym(s):
p38 MAP Kinase Inhibitor XI
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About This Item
Empirical Formula (Hill Notation):
C21H14F2N2O
Molecular Weight:
348.35
UNSPSC Code:
12352200
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assay
≥98% (HPLC)
Quality Level
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
light beige
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable naphthyridine N-oxide compound that acts as a potent, reversible p38α MAP kinase inhibitor (IC50 = 68 nM) and exhibits excellent selectivity among 54-kinases. It acts on the ATP-binding site plus an adjacent hydrophobic pocket. Exhibits desirable ADME (Absorption, Distribution, Metabolism, and Excretion) profile with good microsomal stability, low toxicity, and low reactivity towards cytochrome P450 isozymes. Shown to inhibit lipopolysaccharide-induced TNFα production in a dose-dependent manner (ED50 of 0.5 mg/kg).
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Lumeras, W., et al. 2011. J. Med. Chem.54, 7899.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
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