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506274

Sigma-Aldrich

PACOCF₃ - CAS 141022-99-3 - Calbiochem

A novel Ca2+-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM).

Synonym(s):
PACOCF₃ - CAS 141022-99-3 - Calbiochem, Palmitoyl Trifluoromethyl Ketone
Empirical Formula (Hill Notation):
C17H31F3O
CAS Number:
Molecular Weight:
308.42
MDL number:

Quality Level

assay

≥97% (TLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

shipped in

wet ice

storage temp.

−20°C

General description

A novel Ca2+-independent and reversible inhibitor of phospholipase A2 (PLA2; IC50 = 3.8 µM). May also inhibit Ca2+-dependent PLA2 at much higher concentrations (IC50 = 45 µM).
A novel Ca2+-independent phospholipase A2 inhibitor (IC50 = 3.8 µM). May also inhibit Ca2+-dependent phospholipase A2 at higher concentrations (IC50 = 45 µM)

Packaging

5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: yes
Target IC50: 3.8 µM and 45 µM against phospholipase A2 (PLA2) and Ca2+-dependent PLA2, respectively.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.
Supplied as a solution in ethanol. To change the solvent, evaporate the ethanol with a stream of nitrogen and immediately reconstitute with the solvent of choice. Soluble in DMSO (30 mg/ml). Only minimally soluble in aqueous buffers; do not use basic buffers; unstable at basic pH.

Other Notes

Conde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
Ackermann, E.J., et al. 1995. J. Biol. Chem.270, 445.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificate of Analysis

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Certificate of Quality

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