GR 127935 Hydrochloride - CAS 148642-42-6 - Calbiochem

5-HT 1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 hydrochloride, GR127935 hydrochloride, GR 127935 Hydrochloride - CAS 148642-42-6 - Calbiochem
Empirical Formula (Hill Notation):
C29H31N5O3 · xHCl
CAS Number:
Molecular Weight:
497.59 (free base basis)

storage conditions

+2C to +8C

Quality Level


≥98% (HPLC)





storage condition

OK to freeze
protect from light




water: soluble

storage temp.


General description

A selective 5-HT1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8 )and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behaviour in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC50 = 97 pM.

Biochem/physiol Actions

Primary Target


Toxicity: Standard Handling (A)


Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Rex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior.88, 196.

Przegalinski, E. et al. 2008. Pharmacol. Rep.60, 798.
Bannai, M. et al. 2007. Psychopharmacol.93, 295.
McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther.290, 965.

Pauwels, P. J. et al. 1996. J. Neurochem.66, 65.
Skingle, M. et al. 1996. Behav.Brain Res.73, 157.

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