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Sigma-Aldrich

Glycogen Phosphorylase Inhibitor II, KB228

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Synonym(s):
Glycogen Phosphorylase Inhibitor II, KB228, KB-228
Empirical Formula (Hill Notation):
C16H22N2O7
Molecular Weight:
354.36

Assay

≥98% (HPLC)

Quality Level

form

powder

potency

930 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mg/mL

storage temp.

−20°C

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This Item
5.004875.336605.08318
form

powder

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

color

white

color

off-white

color

yellow

color

white

solubility

DMSO: 100 mg/mL

solubility

DMSO: 100 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 100 mg/mL

General description

A glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.
A glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Glycogen Phosphorylase
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Nagy, L., et al. 2013. PLoS One.8, e69420.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Lilla Nagy et al.
PloS one, 8(7), e69420-e69420 (2013-08-13)
Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target to modulate glucose levels in diabetes. Hereby we present the metabolic effects of a novel, potent, glucose-based GP inhibitor

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