5.08436

Sigma-Aldrich

InSolution AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem

A 50 mM (50 mg/4.17 ml) sterile-filtered solution of AEBSF, Hydrochloride in H₂O.

Synonym(s):
InSolution AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem, 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl, 4-(2-Aminoethyl)benzene-1-sulfonylfluoride, HCl, AEBSF, HCl InSolution
Empirical Formula (Hill Notation):
C8H10FNO2S · xHCl
CAS Number:
Molecular Weight:
203.23 (free base basis)
MDL number:

storage conditions

= -70C

Quality Level

assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

storage temp.

−70°C

InChI

1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

InChI key

WRDABNWSWOHGMS-UHFFFAOYSA-N

General description

Specific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications.

Biochem/physiol Actions

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

A 50 mM (50 mg/4.17 ml) sterile-filtered solution of AEBSF, Hydrochloride (Cat. No. 101500) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C.

Other Notes

Citron, M., et al. 1996. Neuron17, 171.
Ohkubo, I., et al. 1994. J. Biochem.116, 1182.
Mintz, G.R. 1993. BioPharm.6, 34.
Lawson, W.B., et al. 1982. Folia Haematol.109, 52.
Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247.
Markwardt, F., et al. 1973. Thromb. Res.2, 343.

Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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