516569

PPARβ/δ Antagonist, PT-S58

The PPARβ/δ Antagonist, PT-S58 controls the biological activity of PPARβ/δ.

• Synonym(s): PPARβ/δ Antagonist, PT-S58, PPARβ Antagonist II, methyl 3-(N-(4-(tert-butylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate, PPARδ Antagonist II
• Empirical Formula (Hill Notation): C₁₇H₂₂N₂O₅S₂
• Molecular Weight: 398.50
• MDL number: MFCD22666395
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: dark yellow
• solubility: DMSO: 100 mg/mL, clear, amber-yellow
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A cell-permeable, diaryl sulfonamide PPARβ/δ subtype-specific pure competitive antagonist with an IC₅₀ of 98 nM. Antagonizes ligand binding without enabling coregulator interactions. Inhibits the PPARβ/δ specific agonist-induced transcriptional activity in cell cultures.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Naruhn, S., et al. 2011, Mol. Pharm.80, 828.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable