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516620

Sigma-Aldrich

Peroxynitrite

liquid, biological oxidizing agent, Calbiochem®

Synonym(s):

Nitroxyl anion, Peroxynitrous acid

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$187.00

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1 SET
$187.00

About This Item

UNSPSC Code:
51111800
NACRES:
NA.77

$187.00


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Request a Bulk Order

Product Name

Peroxynitrite, Synthesized from isoamyl nitrite and hydrogen peroxide.

Quality Level

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

color

yellow

solubility

soluble (Peroxynitrite is soluble in aqueous buffers that have been pre-purged with an inert gas and pre-cooled to 4°C.)

shipped in

wet ice

storage temp.

−70°C

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FeTPPS A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro.

341492

FeTPPS

MnTBAP Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.

475870

MnTBAP

form

liquid

form

liquid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Upstate®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−70°C

storage temp.

-

storage temp.

2-8°C

storage temp.

−20°C

storage condition

OK to freeze, protect from light, avoid repeated freeze/thaw cycles

storage condition

-

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, desiccated, protect from light

shipped in

wet ice

shipped in

dry ice

shipped in

ambient

shipped in

ambient

General description

Note: 1 set = 2 x 1 ml.
Synthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. It has been implicated in a variety of patho-physiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock. This product decomposes or isomerizes at pH 8 or less; the half-life at pH 7.5 is ~1.5 s. ε302 nm = 1670M-1cm-1 in 0.1 MNaOH.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Oxidizer (K)

Physical form

Supplied in 4.7% NaOH at 160-200 mM.

Preparation Note

Peroxynitrite is soluble in aqueous buffers that have been pre-purged with an inert gas and pre-cooled to 4°C.

Reconstitution

Protect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA94, 14243.
Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardCorrosion

signalword

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Corr. 1B

Storage Class

5.1B - Oxidizing hazardous materials

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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