528108

Sigma-Aldrich

PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem

The PI 3-Kγ Inhibitor II, also referenced under CAS 648449-76-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):
PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem, 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II
Empirical Formula (Hill Notation):
C11H5F2NO4S
CAS Number:
Molecular Weight:
285.22
MDL number:
Pricing and availability is not currently available.

storage conditions

+2C to +8C

Quality Level

assay

≥98% (HPLC)

form

solid

potency

180 nM Ki

mfr. no.

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 10 mg/mL
ethanol: 5 mg/mL

shipped in

ambient

General description

A cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 >20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.

Packaging

5 mg in Plastic ampoule
Packaged under inert gas

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PI 3-Kγ
Target IC50: 250 nM against PI 3-Kγ
Reversible: no
Product competes with ATP.

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bilancio, A., et al. 2006. Blood107, 642.
Camps, M., et al. 2005. Nat. Med.11, 936.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany

WGK 3

Certificate of Analysis
Certificate of Origin

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