528114

PI 3-Kγ Inhibitor VII

The PI 3-Kγ Inhibitor VII, also referenced under CAS 6318-41-8, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): PI 3-Kγ Inhibitor VII, 5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII
• Empirical Formula (Hill Notation): C₁₁H₇NO₄S
• CAS Number: 6318-41-8
• Molecular Weight: 249.24
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 40 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C11H7NO4S/c13-10-9(17-11(14)12-10)4-6-1-2-7-8(3-6)16-5-15-7/h1-4H,5H2,(H,12,13,14)/b9-4+
• InChI key: SDGWAUUPHUBJNQ-RUDMXATFSA-N

Description

General description

A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC₅₀ = 0.07, 0.24, 1.45, and 1.70 M for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 M). Exhibits similar pharmacokinetics as LY 294002 in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Ferrandi, C., et al. 2007. J. Pharmacol. Exp. Ther.322, 923.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable