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528822

Sigma-Aldrich

PARP Inhibitor XII

The PARP Inhibitor XII, also referenced under CAS 489457-67-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

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Synonym(s):
PARP Inhibitor XII, 3-(4-Chlorophenyl)quinoxaline-5-carboxamide
Empirical Formula (Hill Notation):
C15H10ClN3O
CAS Number:
Molecular Weight:
283.71

Quality Level

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light brown

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

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528824300270324473
PARP Inhibitor XII The PARP Inhibitor XII, also referenced under CAS 489457-67-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

Sigma-Aldrich

528822

PARP Inhibitor XII

PARP Inhibitor XIV The PARP Inhibitor XIV, also referenced under CAS 1104546-89-5, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

Sigma-Aldrich

528824

PARP Inhibitor XIV

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

light brown

color

orange

color

off-white

color

white

solubility

DMSO: 10 mg/mL

solubility

DMSO: 10 mg/mL

solubility

DMSO: 5 mg/mL

solubility

water: 50 mg/mL

General description

A potent quinoxaline-based PARP inhibitor with a ~5-fold selectivity towards PARP-2 over PARP-1 (IC50 = 7 and 33 nM, respectively). Reported to be brain-permeant and exhibit good pharmacokinetics.

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Other Notes

Ishida, J., et al. 2006. Bioorg. Med. Chem.14, 1378.
Iwashita, A., et al. 2005. FEBS Lett.579, 1389.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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