Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

528825

Sigma-Aldrich

PARP Inhibitor XV, UPF-1035

The PARP Inhibitor XV, UPF-1035, also referenced under CAS 370872-09-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

PARP Inhibitor XV, UPF-1035, 5-Benzoyloxyisoquinolin-1(2H)-one

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C16H11NO3
CAS Number:
Molecular Weight:
265.26
UNSPSC Code:
12352200

Quality Level

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale beige

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C16H11NO3/c18-15-13-7-4-8-14(12(13)9-10-17-15)20-16(19)11-5-2-1-3-6-11/h1-10H,(H,17,18)

InChI key

FFWUPFYTTMMSTH-UHFFFAOYSA-N

General description

A cell-permeable isoquinolinone compound that acts as an NAD+-binding site-targeting, PARP-2-selective inhibitor (IC50 against murine PARP-2 and bovine PARP-1 = 0.15 and 8.0 µM, respectively). Reported to preferentially inhibit PARP activity in nuclear extracts derived from PARP-1-/- over PARP-1+/+ murine fibroblasts (by 80% and 15%, respectively, at 10 µM), while exhibiting little effect against tankyrase-1-dependent mitotic spindle formation in HeLa cells even at concentrations as high as 100 µM.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Moroni, F., et al. 2009. Br. J. Pharmacol.157, 854.
Pellicciari, R., et al. 2008. ChemMedChem3, 914.
Soluble in DMSO ( mg/ml), aliquot & store at -20*C; stable for 6 months.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service