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537075

Sigma-Aldrich

(±)-Propranolol, Hydrochloride - CAS 3506-09-0 - Calbiochem

A highly lipophilic agent that blocks both β₁ and β₂ adrenergic receptors with equal potency.

Synonym(s):
(±)-Propranolol, Hydrochloride - CAS 3506-09-0 - Calbiochem, (±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl
Empirical Formula (Hill Notation):
C16H21NO2 · xHCl
CAS Number:
Molecular Weight:
259.34 (free base basis)

Quality Level

assay

≥97% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

methanol: soluble
water: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C17H23NO2.ClH/c1-13(2)10-18-11-15(19)12-20-17-9-5-7-14-6-3-4-8-16(14)17;/h3-9,13,15,18-19H,10-12H2,1-2H3;1H

InChI key

RTTYPFXTLKDXPS-UHFFFAOYSA-N

General description

A highly lipophilic agent that blocks both β1 and β2 adrenergic receptors with equal potency. Has no effect on α-adrenergic receptors. Also binds to 5HT-1B receptors with high affinity (Ki = 17 nM) in contrast to 5HT-1D receptors (Ki = 10.2 µM). Readily enters the central nervous system. Blocks phospholipase D-derived diacylglycerol (DAG) formation by inhibiting phosphatidate phosphohydrolase. Useful tool for discriminating between phospholipase D- or phospholipase C-mediated DAG production. An anti-hypertensive agent that is also used in the treatment of cardiac arrhythmias.

Packaging

100 mg in Glass bottle

Biochem/physiol Actions

Primary Target
β1 and β2 adrenergic receptors
Product does not compete with ATP.
Reversible: no
Target Ki: 17 nM for 5HT-1B receptors
Cell permeable: no

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Fujita, K., et al. 1996. FEBS Lett.395, 293.
Glennon, R.A., et al. 1996. Mol. Pharmacol.49, 198.
Thompson, N.T., et al. 1991. Trends Pharmacol. Sci.12, 404.
Hoffman, B.B., and Lefkowitz, R.J. 1990. in The Pharmacological Basis of Therapeutics (Gilman, A.G., et al., Eds.) p. 221, Pergamon Press, New York.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Shubham Dwivedi et al.
Cell death discovery, 7(1), 364-364 (2021-11-24)
The progression of prostate cancer (PC) into neuroendocrine prostate cancer (NEPC) is a major challenge in treating PC. In NEPC, the PC cells undergo neuroendocrine differentiation (NED); however, the exact molecular mechanism that triggers NED is unknown. Peripheral nerves are

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