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5.38096

Sigma-Aldrich

GluN2B NMDA Receptor Antagonist, 93-31 - Calbiochem

Synonym(s):
GluN2B NMDA Receptor Antagonist, 93-31 - Calbiochem, (S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
Empirical Formula (Hill Notation):
C22H30Cl2N2O4S
Molecular Weight:
489.46

assay

≥98% (HPLC)

Quality Level

form

solid (sticky)

potency

0.19 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light yellow to yellow

solubility

DMSO: 100 mg/mL

storage temp.

−20°C

General description

A tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC50 = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED50 ≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC50 = 70 nM) and alpha1-adrenergic receptor (IC50 = 4.9 µM).

Biochem/physiol Actions

Primary Target
GluN2B NMDA Receptor
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yuan, H., et al. 2015. Neuron.85, 1305.
Tahirovic, Y., et al. 2008. J. Med. Chem.51, 5506.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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