538944

Sigma-Aldrich

U-46619 - CAS 56985-40-1 - Calbiochem

Stable thromboxane A₂ mimetic and a vasoconstrictor.

Synonym(s):
U-46619 - CAS 56985-40-1 - Calbiochem, 9,11-Dideoxy-9α,11α-methanoepoxyprostaglandin F
Empirical Formula (Hill Notation):
C21H34O4
CAS Number:
Molecular Weight:
350.49
MDL number:
NACRES:
NA.77

storage conditions

-20C

Quality Level

assay

≥98% (HPLC)
≥98% (TLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

clear colorless

solubility

DMSO: soluble
ethanol: soluble

shipped in

wet ice

InChI

1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18?,19+,20+/m1/s1

InChI key

LQANGKSBLPMBTJ-WTPHSRJXSA-N

General description

Stable thromboxane A2 mimetic and a vasoconstrictor.
Stable thromboxane A2 mimetic.

Packaging

1 mg in Alu drum
Please refer to vial label for lot-specific concentration.

Biochem/physiol Actions

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Stable thromboxane A2 mimetic and a vasoconstrictor.

Warning

Toxicity: Flammable (J)

Physical form

In methyl acetate.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Just prior to use, evaporate to dryness under a stream of nitrogen and dissolve in DMSO or EtOH (100 mg/ml).

Other Notes

Sametz, W., et al. 1999. Eur. J. Pharmacol. 378, 47.
Kaye, D., et al. 1997. Eur. J. Pharmacol. 340, 187.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Target Organs

Central nervous system

Supp Hazards

EUH066

WGK Germany

WGK 2

Flash Point(F)

8.6 °F - Information refers to the main component.

Flash Point(C)

-13 °C - Information refers to the main component.

Serap Erdogmus et al.
Nature communications, 10(1), 5784-5784 (2019-12-21)
G-protein coupled receptors (GPCRs) are versatile cellular sensors for chemical stimuli, but also serve as mechanosensors involved in various (patho)physiological settings like vascular regulation, cardiac hypertrophy and preeclampsia. However, the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive....

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