539684

PKA Inhibitor 6-22 Amide

The PKA Inhibitor 6-22 Amide, also referenced under CAS 121932-06-7, controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): PKA Inhibitor 6-22 Amide, PKI 6-22 Amide, TYADFIASGRTGRRNAI-NH₂, PKA Inhibitor VIII, Protein Kinase A Inhibitor 6-22 Amide, PKI 6-22 Amide, TYADFIASGRTGRRNAI-NH₂, Protein Kinase A Inhibitor 6-22 Amide, PKA Inhibitor VIII
• Empirical Formula (Hill Notation): C₈₀H₁₃₀N₂₈O₂₄
• CAS Number: 121932-06-7
• Molecular Weight: 1868.06
• MDL number: MFCD00133792

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C80H130N28O24/c1-10-37(3)60(63(83)118)106-66(121)41(7)96-72(127)52(32-55(81)113)103-69(124)49(22-17-29-92-80(88)89)100-68(123)47(20-15-27-90-78(84)85)98-57(115)35-94-76(131)62(43(9)111)108-70(125)48(21-16-28-91-79(86)87)99-56(114)34-93-67(122)54(36-109)105-65(120)40(6)97-77(132)61(38(4)11-2)107-74(129)51(30-44-18-13-12-14-19-44)102-73(128)53(33-58(116)117)101-64(119)39(5)95-71(126)50(104-75(130)59(82)42(8)110)31-45-23-25-46(112)26-24-45/h12-14,18-19,23-26,37-43,47-54,59-62,109-112H,10-11,15-17,20-22,27-36,82H2,1-9H3,(H2,81,113)(H2,83,118)(H,93,122)(H,94,131)(H,95,126)(H,96,127)(H,97,132)(H,98,115)(H,99,114)(H,100,123)(H,101,119)(H,102,128)(H,103,124)(H,104,130)(H,105,120)(H,106,121)(H,107,129)(H,108,125)(H,116,117)(H4,84,85,90)(H4,86,87,91)(H4,88,89,92)/t37-,38-,39-,40-,41-,42+,43+,47-,48-,49-,50-,51-,52-,53-,54-,59-,60-,61-,62-/m0/s1
• InChI key: VAKHFAFLRUNHLQ-PEBJKXEYSA-N

Description

General description

A potent and competitive inhibitor of PKA (K_i = 1.7 nM).

A potent and competitive inhibitor of protein kinase A (K_i = 1.7 nM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
PKA

Product does not compete with ATP.

Reversible: no

Target K_i: 1.7 nM against protein kinase A

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Glass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.
Kemp, B.E., et al. 1988. Methods Enzymol.159, 173.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable