539684

Sigma-Aldrich

PKA Inhibitor 6-22 Amide - CAS 121932-06-7 - Calbiochem

The PKA Inhibitor 6-22 Amide, also referenced under CAS 121932-06-7, controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):
PKI 6-22 Amide, TYADFIASGRTGRRNAI-NH₂, Protein Kinase A Inhibitor 6-22 Amide, PKA Inhibitor VIII, PKA Inhibitor 6-22 Amide - CAS 121932-06-7 - Calbiochem, PKI 6-22 Amide, TYADFIASGRTGRRNAI-NH₂, PKA Inhibitor VIII, Protein Kinase A Inhibitor 6-22 Amide
Empirical Formula (Hill Notation):
C80H130N28O24
CAS Number:
Molecular Weight:
1868.06
MDL number:

storage conditions

-20C

Quality Level

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A potent and competitive inhibitor of protein kinase A (Ki = 1.7 nM).
A potent and competitive inhibitor of PKA (Ki = 1.7 nM).

Packaging

1 mg in Plastic ampoule
Yes

Biochem/physiol Actions

Product does not compete with ATP.
Primary Target
PKA
Target Ki: 1.7 nM against protein kinase A
Reversible: no
Cell permeable: no

Warning

Toxicity: Standard Handling (A)

Sequence

H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Glass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.
Kemp, B.E., et al. 1988. Methods Enzymol.159, 173.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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