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552233

Sigma-Aldrich

QX-314

A quaternary lidocaine derivative, permanently charged, and lipophobic.

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Synonym(s):
QX-314
Empirical Formula (Hill Notation):
C16H27BrN2O
CAS Number:
Molecular Weight:
343.30
MDL number:
NACRES:
NA.77

Quality Level

Assay

≥99%

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

solubility

water: 3 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C16H26N2O/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5/h9-11H,6-8,12H2,1-5H3/p+1

InChI key

PYEBKOFMWAMBFV-UHFFFAOYSA-O

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This Item
344827551850309866
QX-314 A quaternary lidocaine derivative, permanently charged, and lipophobic.

Sigma-Aldrich

552233

QX-314

form

lyophilized solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

water: 3 mg/mL

solubility

DMSO: 10 mg/mL

solubility

water: soluble

solubility

water: 50 mg/mL, chloroform: soluble, methanol: soluble

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

General description

A quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.

Biochem/physiol Actions

Cell permeable: no
Primary Target
A powerful blocker of voltage-sensitive Na+ conductance
Product does not compete with ATP.
Reversible: no
fully active in neurophysiological testing

Warning

Toxicity: Irritant (B)

Other Notes

Mooney, R. 1992. J. Neurosci.12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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