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MilliporeSigma

552233

QX-314

≥99% (HPLC), lyophilized solid, voltage-sensitive Na+ conductance blocker, Calbiochem®

Synonym(s):

QX-314

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About This Item

Empirical Formula (Hill Notation):
C16H27BrN2O
CAS Number:
21306-56-9
Molecular Weight:
343.30
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00083182

Key Documents

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Product Name

QX-314, A quaternary lidocaine derivative, permanently charged, and lipophobic.

SMILES string

[N+](CC)(CC)(CC)CC(=O)Nc1c(cccc1C)C

InChI

1S/C16H26N2O/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5/h9-11H,6-8,12H2,1-5H3/p+1

InChI key

PYEBKOFMWAMBFV-UHFFFAOYSA-O

assay

≥99%

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

solubility

water: 3 mg/mL

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

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QX-314 A quaternary lidocaine derivative, permanently charged, and lipophobic.

Sigma-Aldrich

552233

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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form

lyophilized solid

form

solid

form

solid

form

solid

assay

≥99%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥99% (perchloric acid titration)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

10-30°C

storage temp.

10-30°C

storage temp.

10-30°C

storage temp.

10-30°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze

General description

A quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.

Biochem/physiol Actions

Cell permeable: no
Primary Target
A powerful blocker of voltage-sensitive Na+ conductance
Product does not compete with ATP.
Reversible: no
fully active in neurophysiological testing

Other Notes

Mooney, R. 1992. J. Neurosci.12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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